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2. Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus

Author

Ingen-Housz-Oro, S, Schmidt, V, Ameri, MM, Abe, R, Brassard, A, Mostaghimi, A, Paller, AS, Romano, A, Didona, B, Kaffenberger, BH, Ben Said, B, Thong, BYH, Ramsay, B, Brezinova, E, Milpied, B, Mortz, CG, Chu, CY, Sotozono, C, Gueudry, J, Fortune, DG, Dridi, SM, Tartar, D, Do-Pham, G, Gabison, E, Phillips, EJ, Lewis, F, Salavastru, C, Horvath, B, Dart, J, Setterfield, J, Newman, J, Schulz, JT, Delcampe, A, Brockow, K, Seminario-Vidal, L, Jörg, L, Watson, MP, Gonçalo, M, Lucas, M, Torres, M, Noe, MH, Hama, N, Shear, NH, O’Reilly, P, Wolkenstein, P, Romanelli, P, Dodiuk-Gad, RP, Micheletti, RG, Tiplica, GS, Sheridan, R, Rauz, S, Ahmad, S, Chua, SL, Flynn, TH, Pichler, W, Le, ST, Maverakis, E, Walsh, S, French, LE, and Brüggen, MC

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Dental/Oral and Craniofacial Disease, Humans, Stevens-Johnson Syndrome, Consensus, Skin, Disease Progression, Epidermal necrolysis, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Sequelae, Quality of life, Delphi, Other Medical and Health Sciences, Genetics & Heredity, Genetics, Clinical sciences
Abstract

BackgroundLong-term sequelae are frequent and often disabling after epidermal necrolysis (Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)). However, consensus on the modalities of management of these sequelae is lacking.ObjectivesWe conducted an international multicentric DELPHI exercise to establish a multidisciplinary expert consensus to standardize recommendations regarding management of SJS/TEN sequelae.MethodsParticipants were sent a survey via the online tool "Survey Monkey" consisting of 54 statements organized into 8 topics: general recommendations, professionals involved, skin, oral mucosa and teeth, eyes, genital area, mental health, and allergy workup. Participants evaluated the level of appropriateness of each statement on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). Results were analyzed according to the RAND/UCLA Appropriateness Method.ResultsFifty-two healthcare professionals participated. After the first round, a consensus was obtained for 100% of 54 initially proposed statements (disagreement index

Published
2023

3. Diagnose und Therapie der Bienen- und Wespengiftallergie

Author

Ruëff, F., primary, Bauer, A., additional, Becker, S., additional, Brehler, R., additional, Brockow, K., additional, Chaker, A.M., additional, Darsow, U., additional, Fischer, J., additional, Fuchs, T., additional, Gerstlauer, M., additional, Gernert, S., additional, Hamelmann, E., additional, Hötzenecker, W., additional, Klimek, L., additional, Lange, L., additional, Merk, H., additional, Mülleneisen, N.K., additional, Neustädter, I., additional, Pfützner, W., additional, Sieber, W., additional, Sitter, H., additional, Skudlik, C., additional, Treudler, R., additional, Wedi, B., additional, Wöhrl, S., additional, Worm, M., additional, and Jakob, T., additional

Published
2023
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7. S3-Leitlinie: Klassifikation, Diagnostik und Therapie der Urtikaria

Author

Zuberbier, T., primary, Altrichter, S., additional, Bauer, S., additional, Brehler, R., additional, Brockow, K., additional, Dressler, C., additional, Fluhr, J., additional, Gaskins, M., additional, Hamelmann, E., additional, Kühne, K., additional, Merk, H., additional, Mülleneisen, N.K., additional, Nast, A., additional, Olze, H., additional, Ott, H., additional, Pleimes, M., additional, Ruëff, F., additional, Staubach-Renz, P., additional, Wedi, B., additional, and Maurer, M., additional

Published
2023
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8. Wir stellen uns vor: Allergiezentrum der TU München

Author

Darsow, U., primary, Behrends, U., additional, Brockow, K., additional, Chaker, A.M., additional, Grübl, A., additional, Renner, E., additional, Weidlich, S., additional, Weimann, E., additional, Zeumer, M., additional, Zimmermann, G., additional, and Biedermann, T., additional

Published
2022
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12. Flow‐based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper.

Author

Mayorga, C., Çelik, G. E., Pascal, M., Hoffmann, H. J., Eberlein, B., Torres, M. J., Brockow, K., Garvey, L. H., Barbaud, A., Madrigal‐Burgaleta, R., Caubet, J. C., and Ebo, D. G.

Subjects
DRUG allergy, ALLERGIES, TASK forces, NEUROMUSCULAR blocking agents, BASOPHILS
Abstract

Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mirrors the in vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) "Basophil activation test in the evaluation of Drug Hypersensitivity Reactions" from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus‐based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug‐specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti‐inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Schulungen

Author

Brockow, K., primary, Ring, J., additional, Scheewe, S., additional, and Staab, D., additional

Published
2016
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19. Update Leitlinie zum Management IgE-vermittelter Nahrungsmittelallergien – S2k-Leitline der DGAKI

Author

Worm, M., primary, Reese, I., additional, Ballmer-Weber, B., additional, Beyer, K., additional, Bischoff, S.C., additional, Bohle, B., additional, Brockow, K., additional, Claßen, M., additional, Fischer, P.J., additional, Hamelmann, E., additional, Jappe, U., additional, Tebbe, J. Kleine-, additional, Klimek, L., additional, Koletzko, B., additional, Lange, L., additional, Lau, S., additional, Lepp, U., additional, Mahler, V., additional, Nemat, K., additional, Raithel, M., additional, Saloga, J., additional, Schäfer, C., additional, Schnadt, S., additional, Schreiber, J., additional, Szépfalusi, Z., additional, Treudler, R., additional, Wagenmann, M., additional, Werfel, T., additional, and Zuberbier, T., additional

Published
2021
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25. AWMF-Leitlinie zu Akuttherapie und Management der Anaphylaxie – Update 2021

Author

Ring, J., primary, Beyer, K., additional, Biedermann, T., additional, Bircher, A., additional, Fischer, M., additional, Fuchs, T., additional, Heller, A., additional, Hoffmann, F., additional, Huttegger, I., additional, Jakob, T., additional, Klimek, L., additional, Kopp, M.V., additional, Kugler, C., additional, Lange, L., additional, Pfaar, O., additional, Rietschel, E., additional, Rueff, F., additional, Schnadt, S., additional, Seifert, R., additional, Stöcker, B., additional, Treudler, R., additional, Vogelberg, C., additional, Werfel, T., additional, Worm, M., additional, Sitter, H., additional, and Brockow, K., additional

Published
2021
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27. Penicillin-Toleranzinduktion in der Schwangerschaft: Allergologische Stellungnahme zur Empfehlung der aktuellen Leitlinie Diagnostik und Therapie der Syphilis (AWMF-Register-Nr. 059-002)

Author

Wedi, B., primary, Aberer, W., additional, Brockow, K., additional, Dickel, H., additional, Brehler, R., additional, Jakob, T., additional, Kreft, B., additional, Mahler, V., additional, Merk, H.F., additional, Mülleneisen, N., additional, Ott, H., additional, Pfützner, W., additional, Röseler, S., additional, Ruëff, F., additional, Sunderkötter, C., additional, Trautmann, A., additional, Treudler, R., additional, Worm, M., additional, and Wurpts, G., additional

Published
2021
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28. Praktische Empfehlungen zur allergologischen Risikoabschätzung der COVID- 19-Impfung

Author

Worm, M., primary, Bauer, A., additional, Wedi, B., additional, Treudler, R., additional, Pfuetzner, W., additional, Brockow, K., additional, Buhl, T., additional, Zuberbier, T., additional, Fluhr, J., additional, Wurpts, G., additional, Klimek, L., additional, Jacob, T., additional, Merk, H.F., additional, Mülleneisen, N., additional, Roeseler, S., additional, Dickel, D., additional, Raap, U., additional, and Kleine-Tebbe, J., additional

Published
2021
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31. S2k-Leitlinie: Diagnostik bei Verdacht auf eine Betalaktamantibiotika-Überempfindlichkeit

Author

Wurpts, G., primary, Aberer, W., additional, Dickel, H., additional, Brehler, R., additional, Jakob, T., additional, Kreft, B., additional, Mahler, V., additional, Merk, H.F., additional, Mülleneisen, N., additional, Ott, H., additional, Pfützner, W., additional, Röseler, S., additional, Ruëff, F., additional, Sitter, H., additional, Sunderkötter, C., additional, Trautmann, A., additional, Treudler, R., additional, Wedi, B., additional, Worm, M., additional, and Brockow, K., additional

Published
2019
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34. 50 Jahre Universitäts-Hautklinik am Biederstein in München

Author

Eberlein, B., additional, Darsow, U., additional, Eyerich, K., additional, Konstantinow, A., additional, Posch, C., additional, Volz, T., additional, Zink, A., additional, Brockow, K., additional, Hein, R., additional, Köberle, M., additional, Möckel, S., additional, Schnopp, N., additional, and Biedermann, T., additional

Published
2019
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36. COVID-19 vaccination in patients receiving allergen immunotherapy (AIT) or biologicals—EAACI recommendations

Author

Jutel M., Torres M.J., Palomares O., Akdis C.A., Eiwegger T., Untersmayr E., Barber D., Zemelka-Wiacek M., Kosowska A., Palmer E., Vieths S., Mahler V., Canonica W.G., Nadeau K., Shamji M.H., Agache I., Akdis M., Khaitov M., Alvarez-Perea A., Alvaro-Lozano M., Atanaskovic-Markovic M., Backer V., Barbaud A., Bavbek S., de Blay F., Bonini M., Bonini S., van Boven J.F.M., Brockow K., Cazzola M., Chatzipetrou A., Chivato T., Cianferoni A., Corren J., Cristoph-Caubet J., Dunn-Galvin A., Ebisawa M., Firinu D., Gawlik R., Gelincik A., del Giacco S., Mortz C.G., Jurgen Hoffmann H., Hoffmann-Sommergruber K., Klimek L., Knol E., Lauerma A., de Llano L.P., Matucci A., Meyer R., Moreira A., Morita H., Patil S.U., Pfaar O., Popescu F.-D., del Pozo V., Price O.J., van Ree R., Fernandez-Rivas M., Rogala B., Romano A., Santos A., Sediva A., Skypala I., Smolinska S., Sokolowska M., Sturm G., Vultaggio A., Walusiak-Skorupa J., Worm M., University of Zurich, Shamji, Mohamed H, Agache, Ioana, Ear, Nose and Throat, Experimental Immunology, AII - Inflammatory diseases, APH - Global Health, APH - Personalized Medicine, Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)

Subjects
DOWN-REGULATION, COVID-19 Vaccines, Immunology, 610 Medicine & health, IMMUNOGENICITY, 10183 Swiss Institute of Allergy and Asthma Research, VACCINES, INFECTION, Hypersensitivity, Humans, Immunology and Allergy, SARS, 2403 Immunology, Biological Products, T-CELL RESPONSES, SARS-CoV-2, IMMUNE-RESPONSES, Vaccination, AIT, Allergens, Immunoglobulin E, allergy, Asthma, mRNA vaccines, biologicals, Desensitization, Immunologic, SAFETY, 2723 Immunology and Allergy, immunotherapy, INFLUENZA VACCINATION, Covid-19, SEVERE ASTHMA, allergen
Abstract

Immune modulation is a key therapeutic approach for allergic diseases, asthma and autoimmunity. It can be achieved in an antigen-specific manner via allergen immunotherapy (AIT) or in an endotype-driven approach using biologicals that target the major pathways of the type 2 (T2) immune response: immunoglobulin (Ig)E, interleukin (IL)-5 and IL-4/IL-13 or non-type 2 response: anti-cytokine antibodies and B-cell depletion via anti-CD20. Coronavirus disease 2019 (COVID-19) vaccination provides an excellent opportunity to tackle the global pandemics and is currently being applied in an accelerated rhythm worldwide. The vaccine exerts its effects through immune modulation, induces and amplifies the response against the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Thus, as there may be a discernible interference between these treatment modalities, recommendations on how they should be applied in sequence are expected. The European Academy of Allergy and Clinical Immunology (EAACI) assembled an expert panel under its Research and Outreach Committee (ROC). This expert panel evaluated the evidence and have formulated recommendations on the administration of COVID-19 vaccine in patients with allergic diseases and asthma receiving AIT or biologicals. The panel also formulated recommendations for COVID-19 vaccine in association with biologicals targeting the type 1 or type 3 immune response. In formulating recommendations, the panel evaluated the mechanisms of COVID-19 infection, of COVID-19 vaccine, of AIT and of biologicals and considered the data published for other anti-infectious vaccines administered concurrently with AIT or biologicals.

Published
2022

44. Urtikaria

Author

Brockow, K., Abeck, Dietrich, editor, and Cremer, Hansjörg, editor

Published
2015
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